Oncology Certified Nurse (OCN) Nursing Practice Test

Which oral alkylating agent is commonly used to treat brain tumors?

1. Carmustine

2. Temodar

3. Procarbazine

4. Dacarbazine

The correct answer is: Temodar

The commonly used oral alkylating agent to treat brain tumors is Temodar, also known as temozolomide. This medication is particularly effective for glioblastoma multiforme, the most aggressive type of brain tumor. Temodar works by introducing alkyl groups into the DNA structure, leading to DNA damage and subsequent tumor cell death. Its oral bioavailability makes it convenient for outpatient administration, which is advantageous for patients undergoing treatment for brain tumors. In addition to its effectiveness against certain types of brain tumors, Temodar has a favorable toxicity profile compared to some other agents, making it more manageable for patients. Other agents like carmustine or procarbazine may be used in various combinations or situations but are not as commonly administered as a first-line oral treatment for brain tumors. Dacarbazine, although used in some contexts, is typically given by injection rather than orally and is less effective for brain tumor treatment specifically. Therefore, Temodar stands out as the preferred choice among oral alkylating agents for treating brain tumors.